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FDA still finding same cGMP deficiencies at dietary supplement facilities

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FDA investigators who inspect dietary supplement manufacturing facilities for compliance with cGMPs (current good manufacturing practices) are still often finding the same deficiencies more than a decade after the regulations were adopted.

In fiscal year 2018 (FY18), 75 inspections—or about 24 percent of firms that received a Form 483 inspection report for “observations,” or alleged cGMP violations—were cited for failing to establish product specifications for the identity, purity, strength and composition of the finished dietary supplement, FDA data revealed. This was the most common cGMP observation in FY18 year as well as in FY17 when 24 percent of firms (89 inspections) were cited for the same infraction, according to FDA data INSIDER obtained through the Freedom of Information Act (FOIA).

Over the years, FDA has repeatedly emphasized the importance of setting and following specifications for the identity and other key attributes of a dietary supplement. Without doing so, FDA and outside cGMP consultants have said, manufacturers have no reliable way to know and verify what is in their products.

Nearly half (274 inspections, or 46 percent) of the 591 inspections in FY18 didn’t receive a Form 483, which suggests those dietary supplement manufacturing facilities are fully compliant with the cGMPs.

Warning Letters

There may be another silver lining. Data analyzed by the Natural Products Association(NPA) suggested an increasing number of firms cited in Form 483s for failing to establish product specs make the necessary corrections without requiring an admonishment from FDA in a subsequent warning letter.

NPA, a trade association founded in 1936 and led by former FDA officials, reviewed FDA warning letters to analyze alleged infractions of the cGMPs.

In reviewing the data dating back to 2010, NPA identified a change in the most cited cGMP violation. Through the first nine months of 2018, FDA most commonly cited dietary supplement firms in warning letters for failing to establish and follow written procedures for the responsibilities of quality control operations. In FY18 Form 483s, the latter cGMP infraction was the second most cited cGMP observation (52 inspections, representing around 16 percent of all Form 483s).

In the previous three years, the most common cGMP violation reported in FDA warning letters was related to specifications to establish when devising a production and process control system, NPA reported this week in a chart within a news release. The above infraction dropped to the third most-cited cGMP violation in 2018 warning letters, while the second most commonly cited infraction related to recordkeeping requirements for production and process control systems.

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FDA’s new nutrition label regulation for fat-soluble vitamins

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The international unit (IU) has been used to measure fat-soluble vitamins—vitamin A, D and E—for decades. The IU is an arbitrary amount based on the amount of a given nutrient needed to produce a biological effect. Different than milligram or microgram, the IU measurement describes something that we cannot see; the potency or biological activity of a product. While IU seemed to be an innovative idea during the time it was introduced, many would agree that this IU system is now outdated.

In the new regulation for the nutrition facts label, FDA is replacing the unit “IU” for vitamin A, vitamin D and vitamin E with the metric unit. The unit for vitamin A will be changed to micrograms of retinol activity equivalents (mcg RAE), milligram of alpha-tocopherol (mg) for vitamin E while Vitamin D will be changed to microgram, while the IU reading for Vitamin D could be displayed in parentheses. This regulation will come into effect on Jan. 1, 2020 for companies with US$10 million or more in annual sales; and Jan 1, 2021 for companies with less than $10 million in annual sales. It is expected that other countries will follow this new regulation as well to standardize the labelling system. This new supplement/ nutrition facts label hopefully will help consumers to make a better decision in terms of choosing the right vitamin A and vitamin E for their daily consumption.

Vitamin A

Vitamin A is essential vitamin for healthy vision and cellular communication. There are two main ways to obtain vitamin A in the diet, through:

(1)         retinols from animal sources and dairy products;

(2)         pro-vitamin A carotenoid from plant.

Both retinols and pro-vitamin A carotenoid are metabolized in the body into the active form of vitamin A, retinoic acid. However, retinols and pro-vitamin A carotenoid differ in their bioactivities. As an example, it takes different amount of IU from retinol, beta-carotene from food, beta-carotene from supplement or alpha-carotene to make 1 microgram of retinoic acid.

Therefore, it is vital for consumers to check the source and forms of vitamin A to ensure they get sufficient vitamin A according to the recommended dietary intake (RDI). The RDI of the vitamin A has also changed from 5,000 IU (equivalent to 1,500 mcg RAE) to 900 mcg RAE for males and 700 mcg RAE for females respectively.

The conversion of unit of vitamin A from IU to the metric unit, mcg RAE, will take into account the differences in vitamin A activity between retinols and pro-vitamin A carotenoid. In the new unit, 1 RAE will equal to 1 mcg retinol, 12 mcg beta-carotene, 24 mcg alpha-carotene or 24 mcg beta-cryptoxanthin. Hence, the change of IU to mcg RAE for vitamin A is welcomed as this will reflect the actual or reality of vitamin A activity of its different forms—retinol and pro-vitamin A carotenoid.

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Product offerings grow for the anxiety, stress, mood and sleep category

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Qualifying and quantifying the market for products that address anxiety, stress, mood and sleep is a little like trying to nail jelly to the wall or define “obscenity.” Regarding the latter, U.S. Supreme Court Justice Potter Stewart famously remarked in 1964 that “I know it when I see it” to describe his threshold test in Jacobellis v. Ohio. To some extent, this also applies to the market for products that address anxiety, stress, mood and sleep.

Products addressing anxiety, stress, mood and sleep are scattered all over the marketplace. No longer are innovation opportunities limited to over-the-counter (OTC) medications and dietary supplements.

GlobalData identified product innovation oriented around anxiety, stress, mood and sleep that spans nearly 30 different product categories. Product manufacturers are addressing these needs in categories as diverse as fruit, chocolate, yogurt and beer, to air fresheners, fabric conditioners, facial-care products and more.

Companies far and wide want a piece of the pie because the pie is big—and growing. GlobalData puts the global market for sleeping aids (classified as OTC health care products) at $US1.36 billion as of 2016. GlobalData expects this market will grow at a compound annual growth rate (CAGR) of just over 4.1 percent for the period from 2015 to 2020. GlobalData puts the U.S. market for sleeping aids at just under $375 million as of 2016, and projects that this market will expand at a CAGR of 3.5 percent for the period from 2015 to 2020.

But trying to measure a market like sleeping aids is not as easy as it used to be, as a growing amount of sleep-related product innovation is taking place outside of OTC health care products and supplements. It is not unusual today to see functional drinks, milk, tea, food products and even facial-care products promote enhanced sleep. Even within OTC medications, sleep aids have become a moving target as companies attempt to monetize interest in more natural and holistic formulations.

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Omega-3s market outlook

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Omega-3 fatty acids are essential for overall health. Mary Ann Siciliano, national sales manager, Aristra Industries Inc., said omega-3s have been found to be particularly good for heart health, joint and inflammation support, eye health, cognitive function, pregnancy and healthy child development and immune function, among other benefits.

The omega-3s include the essential fatty acid alpha-linolenic acid (ALA), and the longer-chain eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

Plant-based sources of ALA omega-3 include flaxseed, chia seeds, canola, walnut and soybean oils and leafy and green vegetables. The short-chain omega-3 ALA can be converted in the body to the longer-chain omega-3s. However, the body’s ability to convert ALA into EPA and/or DHA is inefficient, making ingestion of pre-formed EPA and DHA beneficial.

The biggest challenge for both consumers and industry affecting consumption of omega-3 food supplements is taste. Marine sources of long-chain fatty acids often yield a “fishy” taste that is unappealing to consumers.

Proprietary research from the Global Organization of EPA and DHA Omega-3s (GOED) showed highest supplement use is occurring in the United States, China and Australia. Statistica 2018 estimated the supplement market for omega-3 supplements in 2025 will reach US$57 billion, compared to $33 billion in 2016. This is indeed a steep growth for an individual supplement segment.

Consumption of omega-3-rich food is reasonably high in the high-population markets of China and India, but that is largely fresh-food based. As these economies evolve and nutrition management in the nouveau riche comes to vogue, the demand for supplements will rise.

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FDA issues guidance on disclosing amount of live microbial ingredients in supplements

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FDA on Thursday recognized the benefits of disclosing on labels the number of live microbials in dietary supplements—an issue of interest to marketers of probiotics.

FDA stopped short of amending its labeling regulations, denying a request filed by the International Probiotics Association (IPA).

However, the agency revealed plans to “exercise enforcement discretion” for companies that chose to declare on the Supplement Facts label the amount of live microbial ingredients based on colony-forming units (CFUs), in addition to disclosing the quantitative amount of certain dietary ingredients based on their weight per FDA regulations.

“We believe that CFUs provide a useful description of the quantity of live microbial dietary ingredients,” FDA explained in a constituent update. “Allowing firms to declare the CFUs within the Supplement Facts label will help consumers more readily identify the amount of living microorganisms for each product and more easily compare products.”

Enforcement discretion

In draft guidance published Sept. 6, 2018, FDA said it intends to exercise its enforcement discretion, provided the following conditions are met:

• The quantity is first listed in terms of weight;

• The declaration of quantity in CFUs is expressed in a manner that is clearly separate and readily distinguishable from the weight, e.g., as a parenthetical or in a subset line;

• The declaration of quantity in CFUs is formatted in clear terms that can easily be understood by a common reader, e.g., 10 billion or 300* (where the unit that “*” is intended to represent, such as million or billion, is a typical measurement of CFUs and is clearly indicated elsewhere in the Supplement Facts label)

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Global Dietary Supplements Market is Expected to Reach around $220.3 bn in 2022

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The Dietary Supplements Market research report highlights realistic data on the Dietary Supplements Market business. It offers the user with meticulous statistics over the latest developments in the Dietary Supplements Market. The Dietary Supplements Market report also offers information about the flexible structure of the market. The report involves essential data that helps in the estimation of the growth of the Dietary Supplements Market.

The report collects the data from different topographical regions of the Dietary Supplements Market market. The research report gathers important details of the Dietary Supplements Market related to the current circumstances of specific regions, growth, and recent trends in the Dietary Supplements Markets. It demonstrates data of various factors playing an important role in the development of Dietary Supplements Market market including market framework.

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The report discusses factors, such as demand, revenue, ability, growth rate, gross margin, and production, affecting the Dietary Supplements Market.

The Dietary Supplements Market report presents the user with exclusive facts and figures. This data helps them for the analysis of the Dietary Supplements Market. The report reviews various reliable institutions for the analysis of the future scope for the market and players in the Dietary Supplements Market. It also enlists various well-established and dominating players in the global market along with their contact details, sales, pictures, and productions.

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Weighing the pros & cons of supplement delivery forms

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Now that you have the perfect formula to add to your product line, what solid dosage delivery form should you choose? Capsules, tablets, softgels or powder? The answer—it depends! This is a decision every brand marketer must make during product design. Each delivery form has its place in the dietary supplement arena. Several factors should be considered when selecting a delivery form to ensure the ingredients are delivered to the body in the most befitting form and the product is convenient and user friendly.

The two-piece hard-shell capsule is the most common delivery form in the supplement space. Most allow a rapid release and require fewer processing aids. Tablets are also widely used, which can be packed with a larger quantity of ingredients, allow time-release delivery and offer a variety of shapes and sizes. A softgel typically consists of a soft gelatin or vegetarian-based shell surrounding a liquid fill. This delivery form is particularly suitable for oil-based ingredients. Powders, as the name implies, consist of a single ingredient or mixture of ingredients in powder form. Powders can be considered the purest of the delivery forms requiring few, if any, processing excipients. Powders are ideal for macronutrients or supplements requiring a large serving size. These solid dosage delivery forms have specific manufacturing processes as well as advantages and disadvantages in form and function.

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Delivery Forms for Dietary Supplements

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As someone who’s been in the supplement and manufacturing industry for more than 30 years, I’m continually perplexed at how so many companies focus on overall product quality without also giving equal consideration to delivery within the body. What’s missing here is science and chemistry. More specifically, application of the proper delivery method required for raw materials to be most effective.

Overlooking such factors leads to powders that unwittingly harden, oxidize, taste bad, mix badly, change color or even become rancid. Following are key insights as to when certain ingredient delivery forms should be used for optimal bioavailability and shelf life.

Powders: This is best used for ingredients such as proteins. The major benefit is that even with a serving that is not exact, it won’t affect overall product benefits. Most protein powders are simple dry blends designed to go into solution, usually water, and consumed in a relatively short amount of time. Leaving a powder in water for too long will cause microbial growth, making it dangerous to consume. Materials that are not soluble, taste bad or are highly hygroscopic are not ideal for powder delivery.

Liquids: Great for ready-to-drink (RTD) products, it offers a quick, no-hassle way to consume an ingredient. However, it limits how much actual active material can be included in a serving. The saturation point of liquids depends on the bulk density of the ingredients. Additionally, water-soluble ingredients must be used, otherwise emulsification and suspension techniques need to be applied. Liquid delivery is not good for bad tasting ingredients because “masking” them properly is quite difficult. Liquid delivery products also typically require preservatives and a low-acid or aseptic production.

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Global Omega 3 Supplement Market Analysis By Top Players, Size, Share Forecasting Up To 2026

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Worldwide Omega 3 Supplement Market Research Report represents the proficient analysis of Omega 3 Supplement industry providing a competitive study of leading market players, Omega 3 Supplement market growth, consumption(sales) volume, Omega 3 Supplement key drivers and limiting factors, future projections for the new-comer to plan their strategies for Omega 3 Supplement business. Further, the report contains study of Omega 3 Supplement market ups and downs of past few years and forecasts sales investment Omega 3 Supplement data from 2017 to 2026.

The Omega 3 Supplement Report outline the vitals details which are based on manufacturing region, Omega 3 Supplement top players, type, applications and so on will gives the transparent view of Omega 3 Supplement Industry. The important presence of different regional and local players of Omega 3 Supplement market is tremendously competitive. The Omega 3 Supplement Report is beneficial to recognize annual revenue of key players, Omega 3 Supplement business strategies, key company profiles and their benefaction to the Omega 3 Supplement market share. The Omega 3 Supplement research contains pictorial representation of important data in the form of graphs, figures, Omega 3 Supplement diagrams and tables to make simplified for the users to understand the Omega 3 Supplement market new trends clearly.

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Focus on Clean Label

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Consumers are increasingly aware of the health and environmental consequences of products they buy. Consequently, they are paying close attention to information on labels, opting for foods, beverages, dietary supplements, and personal care products that offer clear, straightforward information about what’s in—and what’s not in—the products they evaluate.

According to insight from Nielsen: “As all marketers are well aware, today’s consumers are more educated than ever, largely because they have access to more information than ever—and that’s only going to continue. So when it comes time to shop, consumers are putting that knowledge to use, and they’re making their selections carefully and for specific purposes. They’re also willing to pay for products that meet their specific needs, and for many, those needs revolve around knowing exactly what’s in—and not in—the items they buy.”

Consumer survey results from product data company Label Insight indicated that 39% of U.S. consumers said they would switch from the brands they currently buy to others that provide clearer, more accurate product information. Additionally, 73% of consumers surveyed by Nielsen said they feel positively about brands that share the “why behind the buy” information about their products.

Interestingly, 68% said they’re willing to pay more for foods and beverages that don’t contain ingredients they perceive are bad for them. In some cases, consumers are more interested in knowing what’s not included than what is included in the products they buy. In fact, 53% of consumers said the exclusion of undesirable ingredients is more important than the inclusion of beneficial ingredients.

That list of “undesirable ingredients” includes artificial ingredients (flavors, colors, sweeteners, and preservatives), GMOs, antibiotics, and hard-to pronounce or unrecognizable ingredients. Essentially, consumers are looking for simplified formulas, and transparency from the brands they buy.

“Today, the ‘why’ and ‘how’ behind the products have become as important as the product itself, oftentimes becoming the primary decision-making criteria that drives a purchase. This has added an entirely new layer of complexity to the way fast-moving consumer goods (FMCG) companies develop and market their products to consumers,” Nielsen noted.

Transparency and label claims are significant sales drivers. According to Nielsen data, sales of products that make organic claims are up 10% from a year ago, sales of products that make ‘all-natural’ claims are up 7.8%, and sales of products that claim “no additives or artificial ingredients” are up 8.0%. “We can also see increased sales across the broader categories along the progressive scale that describes the attributes within the clean arena.”

From ingredient lists, claims, and descriptors, to the nutrition facts panel, about four in 10 (42%) consumers said they rely on the product label as a source for helpful and accurate information about health and wellness, according to the Hartman Group.

Consumers believe less processed products are self-evident; they are not necessarily looking for a “less processed” label, the firm noted.

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