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Bioavailability of curcumin

As an isolated supplement, curcumin is generally understood to be stronger than turmeric, and is often sold as a single compound. Laboratory supplement production focuses on isolating active ingredients, and there is concern that this process may remove compounds that enhance curcumin efficacy. Some researchers question whether the supporting compounds in turmeric are necessary for curcumin bioavailability. Without turmeric, curcumin absorption and resulting efficacy may be reduced. While both turmeric and curcumin are known to have beneficial properties, it is not understood if the synergistic effects of all constituents (including curcumin) within turmeric are more effective than the extracted potent forms of curcumin alone. Until the research is in, this leaves consumers with the question of what product is best: turmeric or curcumin?

One method currently used to improve absorption for curcumin as a single-compound product is the inclusion of piperine, a compound extracted from black pepper that can enhance curcumin absorption. More research is in the pipeline and science substantiating which are the most active compounds and how they work most effectively in one’s body will bring much-needed foundational insight to the curcumin industry.

According to the 2017 Nutrition Business Journal (NBJ) Supplement Business Report, curcumin growth has exploded from product sales of US$15 million in 2005 to $163 million in 2015 and is still spreading from category to category. The rapid increase in popularity has brought many new products to market and, with that, some claims to product benefits and efficacy that are not yet substantiated with research. Overstated claims result in consumer disappointment at best and negative press at worst. The bad press on a product with a claim unsupported by science can reflect on the entire category, regardless of whether those other products have an issue.

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New Chinese Tariffs Target 60 Billion In U.S Trade; Supplements Escape For Now

The Chinese government has retaliated in the latest escalation of President Trump’s trade war by releasing lists of new tariffs on US products, the highest of which will reach 25%. Experts worry that the fallout could affect the supplement industry.

In July President Trump turned up the heat in the trade dispute with China releasing a new list of 10% tariffs targetings 200 billion in trade with China. The most recent is a direct response.

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Unleash Your Skin’s Internal Defenses

Normally you think of protection from ultraviolet skin aging as something that must take place from outside your body, by blocking out solar radiation. But new research reveals that internal factors are just as critical for optimal skin protection.

Clinical research shows that upon ingestion, safe and readily-metabolized plant extracts furnish your skin with extraordinary protection from photoaging.1 They slow the absorption of harmful ultraviolet (UV) rays and blunt potentially cancer-causing DNA damage inflicted by sun-generated free radicals.2,3

Much has been written about how the sun’s burning ultraviolet rays harm our health and appearance. Yet despite the warnings, more than two million4 people in the US will be diagnosed with skin cancer this year alone. Rates of melanoma—the most dangerous form of skin cancer—have not only doubled over the past 10-20 years, but continue to rise 3% to 7% annually.5

In one study, novel plant extracts demonstrated an impressive 54% reduction in activity of collagen-degrading enzymes and an 86% inhibition of enzymes that break down hyaluronic acid—your skin’s natural moisturizer!6

In this article, you will learn of the mechanisms by which certain phytonutrients can significantly offset the ravages of excessive UV exposure that lead to premature skin aging.

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Current Good Manufacturing Practices & the Private-Label Distributor

Over the past several years, the Food and Drug Administration (FDA) has focused its attention on compliance issues related to the dietary supplement industry, generally, and on current good manufacturing practices (cGMPs), in particular. Indeed, we have seen an increase in the issuance of 483s and warning letters to Private Label Distributors (PLD) for failing to have adequate standard operating procedures related to cGMPs.

The Federal Food, Drug, and Cosmetic Act (FFDCA) prohibits a person from introducing or delivering for introduction, or causing the delivery or introduction, into interstate commerce a dietary supplement that is adulterated for failure to comply with dietary supplement cGMP requirements (FFDCA § 402(g)). The cGMP regulations are located in Title 21 of the Code of Federal Regulations, Part 111.

To be clear, a PLD is ultimately responsible for products introduced or delivered for introduction into interstate commerce carrying its name and must ensure that the company and products are in compliance with all FFDCA requirements and pertinent regulations. Therefore, along with establishing standard operating procedures (SOPs) the PLD must implement directly, it must also develop oversight SOPs to ensure its contract manufacturing and fulfillment companies are in compliance.

The cGMP regulations provide for broad and general requirements. To the extent that these regulations apply to the PLD, step-by-step how-to instructions and detailed explanations must be identified in the SOPs to implement the cGMP requirement. Below is a broad outline of both the direct and oversight SOPs that a PLD must develop.

Oversight SOPs
As indicated, the agency has issued several warning letters emphasizing the importance of oversight SOPs for dietary supplement cGMPs. The letters stated that a dietary supplement distributor using contract manufacturers or labelers may be liable for cGMP violations by its contractors, explicitly noting that “‘agents vested with the responsibility, and power commensurate with that responsibility, to devise whatever means necessary to ensure compliance with the [FFDCA]’ can be held accountable for violations of the [FFDCA].”

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Mucuna Pruriens And L-Dopamine

The mucuna pruriens plant is a now what many people consider a fast growing vine and member of the Fabaceae legume family.  This plant is native to various tropical locations in South America, India, Africa and the West Indies part of the world. The seeds or beans are beige, brown or black color and grow inside a 2-3 inch long curved pod that is known to cause irritation to the skin if touched by human beings. The word mucuna comes from the Tupi Amazonian tribe and Portuguese word “mucunán” and the Latin word prurire (pruriens) which makes reference to the itchy substance in the pod hairs that many people are allergic to. This plant is a legume nitrogen fixer; the plant has been used as an experimental cover crop to restore soil fertility that has been destroyed from agricultural use.

Mucuna is one of the highest natural sources of a unique amino acid called L-dopa or better known as (levodopa) which is an essential precursor to the neurotransmitter dopamine. Adequate levels of dopamine are essential for mental functions, sleep, memory, motor skills, muscle coordination as well as the emotional state of a human being. Dopamine is a chemical that is known to calm and relax the nervous system which basically provides a shield and buffer that helps to essentially dope up the body against outside stresses.  This is a hormone that is essentially a feel good hormone and can be naturally stimulated through various activities such as dancing, exercise and pleasurable experiences through sexual acts.  Dopamine may be present in the body but sometimes is unable to cross the blood-brain barrier which is unlike L-dopamine.  Once in the brain, L-dopamine converts into dopamine through a process called decarboxylation.  L-dopamine is metabolized into dopamine through both the heart and brain. Dopamine is a neurotransmitter without which communication among the nerves within the brain would be impossible. There are several significant diseases of the nervous system associated with low levels or absence of the dopamine hormone.  Using mucuna derived from L-dopamine can be very helpful for any individuals with nerve-anxiety issues, mild to severe neurodegenerative disease or reduced cognitive capacities within the human body.

There are some experts that feel that mucuna is more effective when taken with vitamin B6 (pyridoxine) which is required for proper production and synthesis of neurotransmitters such as dopamine.  However mucuna pruriens benefits have been successfully achieved in the ancient Ayurveda system without the use of B6 supplementation in the human body.  Additionally, some people believe that combining chlorella which is high in the B6 vitamin with mucuna allows the body to utilize the seed powder more efficiently.  Mucuna powdered extracts should always include at least 15% L-dopa for maximum effectiveness within the human body. The usage of this ingredient and release in L-dopamine can also help with reduction of stress as well as lowering the cortisol hormone in the body.

Here at NutraCap Labs we offer Mucuna Pruriens as one of our premium ingredients. Let us help you develop your next product with this ingredient for your supplement line. To get the process started log on to our website at www.nutracapusa.com

All about Maltodextrin

You may not be aware that Maltodextrin is one of the most popular components in almost all weight-gainer or mass gainer products. This ingredient has a significant effect on the enzymatic process which allows individuals to perform better during exercise process as well as keep the muscles fuller in between exercise routines. This is a natural ingredient which is highly useful especially for athletes and bodybuilders and it comes without the risk of side effects like some other products.

Maltodextrin is a complex carbohydrate that helps individuals perform better and provides more endurance to cope with the demands of heavy stress on the body. Despite being a carbohydrate, it functions more by rapidly degrading the enzymatic process. Maltodextrin supplements are usually added to carbohydrate products as well to provide a quick way to replenish carbohydrate stores that may have been depleted during exercise. Maltodextrin carries about 4 calories per gram just like any other carbohydrate. This ingredient is a very good natural source of energy source that facilitates rapid delivery and absorption of important nutrients by the skeletal muscle tissue. This way the body can replenish muscle glycogen that may have been lost during the exercise routine.

Maltodextrin comes from cornstarch and is very easily digestible in the human body. The process is very similar to what occurs inside the body when digesting other carbohydrates as well. Some forms of maltodextrins are polymers of dextrose that are also referred to as glucose polymers coming in the form of dried powders. These particular powders do not contain much fat, fiber or protein although some products are highly known for having soluble fiber and is very useful in reducing fat and excess weight being carried by the body. The majority of these powders are simply carb based and are used to fill glycogen stores within the body.

Maltodextrin is not a very sweet tasting powder like others. Ingredients like Maltodextrin are found in many weight gainer products which help ectomorph body types put on weight when their body refuses to. These weight-gainer or mass gainer supplements contain more calories than normal protein powders to help individuals move up in terms of weight and muscle and consume more than their average daily calorie intake without having to eat so much in their regular meals that may not be providing enough fuel to help them reach the desired weight they are trying to get to.

Maltodextrin has a bland taste and mixes very well with different types of liquids. It also helps with the ability to improve mixture with protein and other liquids. This is why many bodybuilders or fitness athletes prefer maltodextrin because they can mix it with most anything and take it on the go with them throughout a busy day.

Maltodextrin is best mixed with about 12-16ox of water in a shaker cup to help give a fine mixture after shaking it up. You may also blend it with protein powder since maltodextrin can improve the protein supplement’s ability to mix while the protein’s flavor can improve maltodextrin’s taste. Consume the mix pre-workout, during workout or post-workout to provide enough energy to last all exercises or to quickly replenish glycogen and carbohydrate stores.

Here at NutraCap Labs we have Maltodextrin Powder as one of our premium ingredients. Let our staff help you use Maltodextrin to formulate a product for your next supplement line. To get the process started visit www.nutracapusa.com today.

The Benefits of Carbohydrate Powder

Supplementation products have been available for years in every nutrition store across the globe. Products like protein, branch chain amino acids, creatine, and weight gainer products. Now there is a new product to add to this list that comes in the form of carbohydrate powder. This product is derived from new formulations that allow one to ingest carbohydrates at a rapid uptake pace for faster glycogen store and recovery in skeletal muscle tissue. So what do these carbohydrate powders do and how exactly do they work when applied into workout supplementation.

When an athlete is building muscle, a fast combination of a fast acting protein as well as a fast acting carbohydrate should be added to your post workout regimen. This period of time is referred to as the anabolic window. During this time period your body can drastically absorb nutrients like a sponge of water. By in taking a fast carbohydrate this leaves your muscle full and refueled for your next workout the following day. Carbohydrate powders are great because they can fuel the muscle and do it in a sugar free manner. These powders are made with the best formulations to give you a carbohydrate that will aid in muscle recovery without a minor response in insulin activity to help you get bigger and leaner from your workout regimen.

Another aspect that carbohydrate powders directly affect is endurance. Adding these powders during your workout can help to keep you training harder and for longer periods of time. Carbohydrates are mainly designed with complex carbohydrates that actually replenish energy stores faster than simple carbohydrates and give you no dizziness, no bloating, and no crash after the training session. These carbohydrates act fast and give much needed energy during your lowest point of your training session or athletic competition.

Carbohydrate powder can also be used in a variety of daily activities. When the body is craving a snack instead of having simple sugars you can implement a carbohydrate powder into your regiment which will aid in a low glycemic response, cure appetite cravings, and also help with managing weight. Carbohydrate powders can also be using in recipes as well. The tasteless powder can also be used in pancake, cereal, cake, oatmeal, and muffin mixes and makes a great addition to sports energy drinks to help provide hydration and recovery without bloat associated with other products.

Here at NutraCap Labs we offer carbohydrate powder blends. With these awesome blends we can leave them unflavored or flavor them with a wide variety of flavors available through our flavoring system. For more on the process please visit www.nutracapusa.com

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