Overview Description

Affron® is a premium saffron ingredient standardized to 3.5% Lepticrosalides™, which is responsible for the beneficial properties and organoleptic properties of affron®. … Affron® genuine quality relies on local trusted sourcing, the selection of the Spanish species Crocus sativus L.


Saffron Crocus (Crocus Sativus)


Saffron can be used for menstrual cramps and regulation of premenstrual syndrome (PMS). 

It can be used to prevent premature ejaculation and infertility.

Saffron has also been used as an aphrodisiac.

It is the main ingredient in (alopecia) to help alleviate baldness

It helps to reduce blood pressure as it has antihypertensive properties on the heart and or total peripheral resistance, or possibly both.

Crocus Sativus has an anticonvulsant constituent, safranal, which was evaluated in mice and showed reduced seizure duration, delaying the onset of tonic convulsions.

Anti-genotoxic and cytotoxic effects of saffron suggest that saffron itself, as well as its carotenoid components of Crocus Sativus might be used as potential cancer chemopreventive agents.

Indications show it has a potent stimulatory effect on β2-adrenoreceptors, which is partially due to its constituent, safranal.

A possible anti-histamine effect on histamine receptors was also suggested.

A study has indicated the efficacy of Crocus Sativus in the treatment of mild-to-moderate depression.

Saffron, crocin and crocetin, improved memory and learning skills in ethanol-induced learning behavior impairments in mice and rats.

Studies have shown the potential of saffron as an antioxidant.

Crocus Sativus exhibited antinociceptive effects in chemically induced pain tests as well as acute and/or chronic anti-inflammatory activity. This might be due to the presence of flavonoids, tannins, anthocyanins, alkaloids, and saponins.

Forms and Sources

Affron® Saffron Crocus (Crocus Sativus)

Side Effects and Interactions

Some possible side effects include dry mouth, anxiety, agitation, drowsiness, low mood, sweating, nausea or vomiting, constipation or diarrhea, change in appetite, flushing, and headache. Allergic reactions can occur in some people.

How to Label

Affron® (Crocus Sativus)

Research & Studies (References)

affron ® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial

affron® increased mood, reduced anxiety and managed stress without side effects, offering a natural alternative to standard treatments.


affron ®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study

The administration of a standardised saffron extract (affron®) for 8 weeks improved anxiety and depressive symptoms in youth with mild-to-moderate symptoms, at least from the perspective of the adolescent. However, these beneficial effects were inconsistently corroborated by parents.


Crocus sativus L.: A comprehensive review

Crocus sativus L. belonging to the family Iridaceae (syn – kesar) comprises the dried red stigma and is widely cultivated in Iran and other countries such as India and Greece. Saffron contains more than 150 volatile and aroma-yielding compounds mainly terpenes, terpene alcohol, and their esters.


The Effect of Crocus sativus L. and Its Constituents on Memory: Basic Studies and Clinical Applications

Crocus sativus L. (C. sativus) is a perennial herb member of the Iridaceae family, the line of Liliaceae. This plant is cultivated in many countries such as Azerbaijan, China, France, Greece, Egypt, India, Iran, Israel, Italy, Mexico, Morocco, Spain, and Turkey. Its product is the well-known spice called saffron. Saffron, in filaments, is the dried dark-red stigmas of C. sativus flower

The potential role of saffron and crocin as adjunctive agents, in combination with an AChE inhibitor or memantine, for the treatment of memory disorders has not been investigated so far.


New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies

This study concludes that safranal and crocin represent useful leads for the discovery of novel hMAO inhibitors for the clinical management of psychiatric and neurodegenerative disorders.



It has been demonstrated  that crocin posseses antiapoptotic effects  on  non‐cancerous  cells.  Crocin  suppresses  cell  death  induced  by tumour necrosis factor‐alpha  (TNF‐α), cysteine protease mRNAs and simultaneously restores the  cytokine‐induced reduction of TNF‐α and mRNA expression6.  U. Crocetin and haemorrahagic shock: Crocetin, a  saffron‐derived  carotenoid, was  shown  to improve  post  shock  recovery  of  cellular  adenosine  triphosphate  and  to  increase  overall survival in an experimental model of hemorrhagic shock.  In  this  model,  crocetin  caused  the  suppression  and  subsequent  expression of messenger ribonucleic acid  for  tumor necrosis  factor,  interleukin‐1 and inducible nitric oxide synthase44. 


Antidepressant properties of bioactive fractions from the extract of Crocus sativus L.

All these results suggest that the low polarity parts of C. sativus corms should be considered as a new plant material for curing depression, which merit further studies regarding antidepressive-like activities of chemical compounds isolated from the two fractions and mechanism of action.


Effects of saffron (Crocus sativus) on sexual dysfunction among men and women: A systematic review and meta-analysis

In general, saffron was proven effective in improving sexual dysfunction and its subscales among participants; this effect was different on different dimensions of sexual dysfunction.


Clinical evidence on the effects of saffron (Crocus sativus L.) on cardiovascular risk factors: A systematic review meta-analysis

Present meta-analysis suggests that saffron might be beneficial in several outcomes related with cardiovascular disease.


Crocus sativus restores dopaminergic and noradrenergic damages induced by lead in Meriones shawi: A possible link with Parkinson’s disease

In this study, we have revealed a new pharmacological potential of Crocus sativus that can be used as a neuroprotective product for neurodegenerative disorders, especially, which implying dopaminergic and noradrenergic injuries, like PD, triggered by heavy metals.


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